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Rprofile not executed in R 2.2.0 alpha for Windows

Do you mean R_HOME/etc/Rprofile (not Profile)?  That is not supposed to be 
executed: see ?Startup.  See the NEWS item

     o   R_HOME/etc/Rprofile is no longer looked for if
         R_HOME/etc/Rprofile.site does not exist.  (This has been
         undocumented since R 1.4.0.)

We will rename the file to Rprofile.site (and update it).
On Thu, 15 Sep 2005, John Fox wrote: