rprofile.site

Hi all,
i just installed R 2.12.1 and Tinn-R 2.3.7.1. My OS is Windows 7 32bit.

Here is my question:
Do I have to execute the rprofile.site manually every time I start a 
R/Tinn-R session? Because it seems that way.
Here is the error code I receive after sending "selection(echo=TRUE):

source(.trPaths[5], echo=TRUE, max.deparse.length=150)

It doesn't do that after I configure 
(R>configure>permanent(rprofile.site)) but after i closed R/Tinn-R I 
have to configure R again. Is that necessary?

Thank you,
Julian