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Pre-model Variable Reduction

Mark Difford wrote:
Mark,

Slightly more relevant is the unsupervised sparse principal component 
methods described in the following references.  If anyone knows of 
better references for this please let me know.  -Frank


@Article{zou06spa,
   author = 		 {Zhou, Hui and Hastie, Trevor and Tibshirani, Robert},
   title = 		 {Sparse principal component analysis},
   journal = 	 J Comp Graph Stat,
   year = 		 2006,
   volume =		 15,
   pages =		 {265-286},
   annote =		 {gene microarray;lasso/elastic net;multivariate
analysis;data reduction;singular value
decomposition;thresholding;principal components analysis that shrinks
some loadings to zero}
}
@Article{wit08tes,
   author = 		 {Witten, Daniela M. and Tibshirani, Robert},
   title = 		 {Testing significance of features by lassoed principal 
components},
   journal = 	 Annals Appl Stat,
   year = 		 2008,
   volume = 	 2,
   number = 	 3,
   pages = 	 {986-1012},
   annote = 	 {reduction in false discovery rates over using a vector of 
t-statistics;borrowing strength across genes;``one would not expect a 
single gene to be associated with the outcome, since, in practice, many 
genes work together to effect a particular phenotype.  LPC effectively 
down-weights individual genes that are associated with the outcome but 
that do not share an expression pattern with a larger group of genes, 
and instead favors large groups of genes that appear to be 
differentially-expressed.'';regress principal components on outcome}
}