lme RE variance computation
As I understand it lme (in R v1.9.x) estimates random effect variances on a log scale, constraining them to be positive. Whilst this seems sensible, it does lead to apparently biased estimates if the variance is actually zero - which makes our simulation results look strange. Whilst we need to think a bit deeper about it - I still haven't got my head around what a negative variance could mean - does anyone know a way to take away the contraint and allowing zero or negative variances? Steve. Dr Steve Roberts steve.roberts at man.ac.uk Senior Lecturer in Medical Statistics, CMMCH NHS Trust and University of Manchester Biostatistics Group, 0161 275 5192 / 0161 276 5785