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Is there a quicker way to drop a data frame column than setting it to NULL?

If I want to drop columns x, y, z from dataframe df, is there a better
alternative to

df$x = NULL
df$y = NULL
df$z = NULL

There are sufficiently many columns remaining to make 

df = subset(df, select = c(a,b,c,d[etc]))

cumbersome.

Thank you.