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equipment

"Ruud H. Koning" <info at rhkoning.com> writes:
Except for the time-varying Cox thing, this doesn't seem too hard:
[1] "V1"  "V2"  "V3"  "V4"  "V5"  "V6"  "V7"  "V8"  "V9"  "V10" "V11" "V12"
[13] "V13" "V14" "V15"
[1] 2.62 0.61 3.24 0.00 0.00
used (Mb) gc trigger (Mb)
Ncells  431614 11.6     741108 19.8
Vcells 1079809  8.3    6817351 52.1

That's on the fastest machine I have access to, a 2.8GHz Xeon (Dual,
but not with threaded BLAS lib). About three times slower on a 900 MHz
PIII. For GLM you'll do similar  operations iterated say 5 times, and
if you have factors and interactions among your predictors, you'll get
essentially an increase proportional to the number of parameters in
the model. 

Time-dependent Cox in full generality has complexity proportional to
the square of the data set (one regression computation per death)
which could be prohibitive, but there are often simplifications,
depending on the nature of the time dependency.