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Enormous Datasets

It depends on what you want to do with that data in R.  If you want to play
with the whole data, just storing it in R will require more than 2.6GB of
memory (assuming all data are numeric and are stored as doubles):
[1] 2670.288

That's not impossible, but you'll need to be on a computer with quite a bit
more memory than that, and running on an OS that supports it.  If that's not
feasible, you need to re-think what you want to do with that data in R
(e.g., read in and process a small chunk at a time, or read in a random
sample, etc.).

Andy