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system() command not working

I can't find the discussion on R-SIG-Mac list. But you can try this:

MRT_DATA_DIR=<whatever> open -a Rstudio

or  

MRT_DATA_DIR=<whatever> open -a R

Try it and see what happens.
It may even be possible to put something in .Rprofile  setting your environment variables.

Berend Hasselman