Hierarchical Cluster Analysis with large dataset

(Offlist, since this is just a personal comment).

I cannot help you -- but it sounds like the sort of thing that you
should look for on the BioconductoR list.

But I wonder how you could possibly interpret the results even if you
could get them. I would think they would be more noise than signal,
and making sense of such a mess would be hopeless. Maybe you need to
rethink your approach.

No need to respond to me, of course.

Cheers,
Bert

On Sun, Nov 3, 2013 at 1:42 AM, Petar Milin

Hello!
Can anyone give me advice on running Hierarchical Cluster Analysis on large
datasets? For example, 80000x10000. Calculating distances on such a
dataframe seems impossible even on very powerful computer.

Also, any other advice that would lead to reduction of dimensionality,
i.e., cluster/group variables would be more than welcomed.

Many thanks,
PM

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Bert Gunter
Genentech Nonclinical Biostatistics

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