AFT-model with time-dependent covariates
The coding for an AFT model with time-dependent covariates will be very hard, and I don't know of anyone who has done it. (But I don't keep watch of other survival packages, so something might be there). In a Cox model, a subject's risk depends only on the current value of his/her covariates; in an AFT model the risk depends on the entire covariate history. (My 'accelerated age' is the sum of all the extra years I have ever gained). Coding this is not theoretically complex, but would be a pain-in-the-rear amount of bookkeeping. Terry Therneau