Adjusting confidence intervals for paired t-tests of multiple endpoints
Erich Studerus <erich.studerus <at> bli.uzh.ch> writes:
Dear R-users, In a randomized placebo-controlled within-subject design, subjects recieved a psycho-active drug and placebo. Subjects filled out a questionnaire containing 15 scales on four different time points after drug administration. In order to detect drug effects on each time point, I compared scale values between placebo and drug for all time conditions and scales, which sums up to 4*15=60 comparisons.
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Now, I want to adjust the confidence intervals for multiple comparisons.
For simple cases, see p.adjust or TukeyHSD (more limited). For complex cases, see simint and friends in package multcomp. Dieter