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Need advice on using R with large datasets

"Roger D. Peng" <rpeng at jhsph.edu> writes:
There are a few such machines around among R users, and R seems to
work OK on them. One slight gotcha is that the Fortran numeric
libraries (Lapack, ATLAS) tend to use integer indexing, which might
overflow for large objects. Things like data frames which consist of
multiple subobjects might be less sensitive to this.