HI, BP.stack5 is the one without missing values. na.omit(....).? Otherwise, I have to use the option na.action=.. in the ?geese() statement You need to read about the correlation structures.? IN unstructured option, more number of parameters needs to be estimated,? In repeated measures design, when the underlying structure is not known, it would be better to compare using different options (exchangeable is similar to compound symmetry) and select the one which provide the least value for AIC or BIC.? Have a look at http://stats.stackexchange.com/questions/21771/how-to-perform-model-selection-in-gee-in-r It's not clear to me? "reference to write about missing values". ?? A.K. ----- Original Message ----- From: Usha Gurunathan <usha.nathan at gmail.com> To: arun <smartpink111 at yahoo.com> Cc: Sent: Monday, January 7, 2013 6:12 PM Subject: Re: [R] random effects model Hi AK 2)I shall try putting exch. and check when I get home. Btw, what is BP.stack5? is it with missing values or only complete cases? I guess I am still not clear about the unstructured and exchangeable options, as in which one is better. 1)Rgding the summary(p): NA thing, I tried putting one of my gee equation. Can you suggest me a reference to write about" missing values and the implications for my results" Thanks.
On 1/8/13, arun <smartpink111 at yahoo.com> wrote:
HI, Just to add: fit3<-geese(hibp~MaternalAge*time,id=CODEA,data=BP.stack5,family=binomial,corstr="exch",scale.fix=TRUE) #works ? summary(fit3)$mean["p"] #? ? ? ? ? ? ? ? ? ? ? ? ? ? p #(Intercept)? ? ? ? 0.00000000 #MaternalAge4? ? ? ? 0.49099242 #MaternalAge5? ? ? ? 0.04686295 #time21? ? ? ? ? ? ? 0.86164351 #MaternalAge4:time21 0.59258221 #MaternalAge5:time21 0.79909832 fit4<-geese(hibp~MaternalAge*time,id=CODEA,data=BP.stack5,family=binomial,corstr="unstructured",scale.fix=TRUE) #when the correlation structure is changed to "unstructured" #Error in `contrasts<-`(`*tmp*`, value = contr.funs[1 + isOF[nn]]) : ? # contrasts can be applied only to factors with 2 or more levels #In addition: Warning message: #In is.na(rows) : is.na() applied to non-(list or vector) of type 'NULL' Though, it works with data(Ohio) fit1<-geese(resp~age+smoke+age:smoke,id=id,data=ohio1,family=binomial,corstr="unstructured",scale.fix=TRUE) ? summary(fit1)$mean["p"] #? ? ? ? ? ? ? ? ? ? ? p #(Intercept)? 0.00000000 #age-1? ? ? ? 0.60555454 #age0? ? ? ? 0.45322698 #age1? ? ? ? 0.01187725 #smoke1? ? ? 0.86262269 #age-1:smoke1 0.17239050 #age0:smoke1? 0.32223942 #age1:smoke1? 0.36686706 By checking: ? with(BP.stack5,table(MaternalAge,time)) #? ? ? ? ? time #MaternalAge? 14? 21 ? #? ? ? ? 3 1104? 864 ? ? #? ? ? 4? 875? 667 ? ? #? ? 5? 67? 53 #less number of observations ? BP.stack6 <- BP.stack5[order(BP.stack5$CODEA, BP.stack5$time),] ? head(BP.stack6)? # very few IDs with? MaternalAge==5 #? ? ? X CODEA Sex MaternalAge Education Birthplace AggScore IntScore #1493 3.1? ? 3? 2? ? ? ? ? 3? ? ? ? 3? ? ? ? ? 1? ? ? ? 0? ? ? ? 0 #3202 3.2? ? 3? 2? ? ? ? ? 3? ? ? ? 3? ? ? ? ? 1? ? ? ? 0? ? ? ? 0 #1306 7.1? ? 7? 2? ? ? ? ? 4? ? ? ? 6? ? ? ? ? 1? ? ? ? 0? ? ? ? 0 #3064 7.2? ? 7? 2? ? ? ? ? 4? ? ? ? 6? ? ? ? ? 1? ? ? ? 0? ? ? ? 0 #1? ? 8.1? ? 8? 2? ? ? ? ? 4? ? ? ? 4? ? ? ? ? 1? ? ? ? 0? ? ? ? 0 #2047 8.2? ? 8? 2? ? ? ? ? 4? ? ? ? 4? ? ? ? ? 1? ? ? ? 0? ? ? ? 0 ? #? ? ? ? Categ time Obese Overweight hibp #1493 Overweight? 14? ? 0? ? ? ? ? 0? ? 0 #3202 Overweight? 21? ? 0? ? ? ? ? 1? ? 0 #1306? ? ? Obese? 14? ? 0? ? ? ? ? 0? ? 0 #3064? ? ? Obese? 21? ? 1? ? ? ? ? 1? ? 0 #1? ? ? ? Normal? 14? ? 0? ? ? ? ? 0? ? 0 #2047? ? Normal? 21? ? 0? ? ? ? ? 0? ? 0 BP.stack7<-BP.stack6[BP.stack6$MaternalAge!=5,] ? BP.stack7$MaternalAge<-factor(as.numeric(as.character(BP.stack7$MaternalAge) ? fit5<-geese(hibp~MaternalAge*time,id=CODEA,data=BP.stack7,family=binomial,corstr="unstructured",scale.fix=TRUE) #Error in `contrasts<-`(`*tmp*`, value = contr.funs[1 + isOF[nn]]) : ? # contrasts can be applied only to factors with 2 or more levels ? with(BP.stack7,table(MaternalAge,time))? #It looks like the combinations are still there #? ? ? ? ? time #MaternalAge? 14? 21 ? #? ? ? ? 3 1104? 864 ? ? #? ? ? 4? 875? 667 It works also with corstr="ar1".? Why do you gave the option "unstructured"? A.K. ----- Original Message ----- From: rex2013 <usha.nathan at gmail.com> To: r-help at r-project.org Cc: Sent: Monday, January 7, 2013 6:15 AM Subject: Re: [R] random effects model Hi A.K Below is the comment I get, not sure why. BP.sub3 is the stacked data without the missing values. BP.geese3 <- geese(HiBP~time*MaternalAge,data=BP.sub3,id=CODEA, family=binomial, corstr="unstructured", na.action=na.omit)Error in `contrasts<-`(`*tmp*`, value = contr.funs[1 + isOF[nn]]) : ? contrasts can be applied only to factors with 2 or more levels Even though age has 3 levels; time has 14 years & 21 years; HIBP is a binary response outcome. 2) When you mentioned summary(m1)$mean["p"] what did the p mean? i used this in one of the gee command, it produced NA as answer? Many thanks On Mon, Jan 7, 2013 at 5:26 AM, arun kirshna [via R] < ml-node+s789695n4654795h72 at n4.nabble.com> wrote:
Hi,
I am? not very familiar with the geese/geeglm().? Is it from
library(geepack)?
Regarding your question:
"
Can you tell me if I can use the geese or geeglm function with this data
eg: : HIBP~ time* Age
Here age is a factor with 3 levels, time: 2 levels, HIBP = yes/no.
From your original data:
BP_2b<-read.csv("BP_2b.csv",sep="\t")
head(BP_2b,2)
#? CODEA Sex MaternalAge Education Birthplace AggScore IntScore Obese14
#1? ? 1? NA? ? ? ? ? 3? ? ? ? 4? ? ? ? ? 1? ? ? NA? ? ? NA? ? ? NA
#2? ? 3? 2? ? ? ? ? 3? ? ? ? 3? ? ? ? ? 1? ? ? ? 0? ? ? ? 0? ? ? 0
? # Overweight14 Overweight21 Obese21 hibp14 hibp21
#1? ? ? ? ? NA? ? ? ? ? NA? ? ? NA? ? NA? ? NA
#2? ? ? ? ? ? 0? ? ? ? ? ? 1? ? ? 0? ? ? 0? ? ? 0
If I understand your new classification:
BP.stacknormal<- subset(BP_2b,Obese14==0 & Overweight14==0 & Obese21==0 &
Overweight21==0)
BP.stackObese <- subset(BP_2b,(Obese14==1& Overweight14==0 &
Obese14==1&Overweight14==1)|(Obese14==1&Overweight14==1 & Obese21==1 &
Overweight21==0)|(Obese14==1&Overweight14==0 & Obese21==0 &
Overweight21==0)|(Obese14==0 & Overweight14==0 & Obese21==1 &
Overweight21==0)|(Obese14==0 & Overweight14==0 & Obese21==1 &
Overweight21==1)|(Obese14==0 & Overweight14==1 & Obese21==1
&Overweight21==1)|(Obese14==1& Overweight14==1 & Obese21==1&
Overweight21==1)) #check whether there are more classification that fits
to
#Obese
? BP.stackOverweight <- subset(BP_2b,(Obese14==0 & Overweight14==1 &
Obese21==0 & Overweight21==1)|(Obese14==0 &Overweight14==1 & Obese21==0 &
Overweight21==0)|(Obese14==0 & Overweight14==0 & Obese21==0 &
Overweight21==1))
BP.stacknormal$Categ<-"Normal"
BP.stackObese$Categ<-"Obese"
BP.stackOverweight$Categ <- "Overweight"
BP.newObeseOverweightNormal<-na.omit(rbind(BP.stacknormal,BP.stackObese,BP.stackOverweight))
? nrow(BP.newObeseOverweightNormal)
#[1] 1581
BP.stack3 <-
reshape(BP.newObeseOverweightNormal,idvar="CODEA",timevar="time",sep="_",varying=list(c("Obese14","Obese21"),c("Overweight14","Overweight21"),c("hibp14","hibp21")),v.names=c("Obese","Overweight","hibp"),direction="long")
library(car)
BP.stack3$time<-recode(BP.stack3$time,"1=14;2=21")
head(BP.stack3,2)
? #? CODEA Sex MaternalAge Education Birthplace AggScore IntScore? Categ
time
#8.1? ? 8? 2? ? ? ? ? 4? ? ? ? 4? ? ? ? ? 1? ? ? ? 0? ? ? ? 0 Normal
14
#9.1? ? 9? 1? ? ? ? ? 3? ? ? ? 6? ? ? ? ? 2? ? ? ? 0? ? ? ? 0 Normal
14
? #? Obese Overweight hibp
#8.1? ? 0? ? ? ? ? 0? ? 0
Now, your formula: (HIBP~time*Age), is it MaternalAge?
If it is, it has three values
unique(BP.stack3$MaternalAge)
#[1] 4 3 5
and for time (14,21) # If it says that geese/geeglm, contrasts could be
applied with factors>=2 levels, what is the problem?
If you take "Categ" variable, it also has 3 levels (Normal, Obese,
Overweight).
? BP.stack3$MaternalAge<-factor(BP.stack3$MaternalAge)
? BP.stack3$time<-factor(BP.stack3$time)
library(geepack)
For your last question about how to get the p-values:
# Using one of the example datasets:
data(seizure)
? ? ? seiz.l <- reshape(seizure,
? ? ? ? ? ? ? ? ? ? ? ? varying=list(c("base","y1", "y2", "y3", "y4")),
? ? ? ? ? ? ? ? ? ? ? ? v.names="y", times=0:4, direction="long")
? ? ? seiz.l <- seiz.l[order(seiz.l$id, seiz.l$time),]
? ? ? seiz.l$t <- ifelse(seiz.l$time == 0, 8, 2)
? ? ? seiz.l$x <- ifelse(seiz.l$time == 0, 0, 1)
? ? ? m1 <- geese(y ~ offset(log(t)) + x + trt + x:trt, id = id,
? ? ? ? ? ? ? ? ? data=seiz.l, corstr="exch", family=poisson)
? ? ? summary(m1)
? summary(m1)$mean["p"]
#? ? ? ? ? ? ? ? ? ? p
#(Intercept) 0.0000000
#x? ? ? ? ? 0.3347040
#trt? ? ? ? 0.9011982
#x:trt? ? ? 0.6236769
#If you need the p-values of the scale
? ? summary(m1)$scale["p"]
? #? ? ? ? ? ? ? ? ? p
#(Intercept) 0.0254634
Hope it helps.
A.K.
----- Original Message -----
From: rex2013 <[hidden
email]<http://user/SendEmail.jtp?type=node&node=4654795&i=0>>
To: [hidden email] <http://user/SendEmail.jtp?type=node&node=4654795&i=1>
Cc:
Sent: Sunday, January 6, 2013 4:55 AM
Subject: Re: [R] random effects model
Hi A.K
Regarding my question on comparing normal/ obese/overweight with blood
pressure change, I did finally as per the first suggestion of stacking the
data and creating a normal category . This only gives me a obese not obese
14, but when I did with the wide format hoping to? get? a
obese14,normal14,overweight 14 Vs hibp 21, i could not complete any of the
models.
This time I classified obese=1 & overweight=1 as obese itself.
Can you tell me if I can use the geese or geeglm function with this data
eg: : HIBP~ time* Age
Here age is a factor with 3 levels, time: 2 levels, HIBP = yes/no.
It says geese/geeglm: contrast can be applied only with factor with 2 or
more levels. What is the way to overcome this. Can I manipulate the data
to
make it work.
I need to know if the demogrphic variables affect change in blood pressure
status over time?
How to get the p values with gee model?
Thanks
On Thu, Jan 3, 2013 at 5:06 AM, arun kirshna [via R] <
[hidden email] <http://user/SendEmail.jtp?type=node&node=4654795&i=2>>
wrote:
HI Rex,
If I take a small subset from your whole dataset, and go through your
codes:
BP_2b<-read.csv("BP_2b.csv",sep="\t")
? BP.sub<-BP_2b[410:418,c(1,8:11,13)] #deleted the columns that are not
needed
? BP.stacknormal<- subset(BP.subnew,Obese14==0 & Overweight14==0)
BP.stackObese <- subset(BP.subnew,Obese14==1)
? BP.stackOverweight <- subset(BP.subnew,Overweight14==1)
BP.stacknormal$Categ<-"Normal14"
BP.stackObese$Categ<-"Obese14"
BP.stackOverweight$Categ <- "Overweight14"
BP.newObeseOverweightNormal<-rbind(BP.stacknormal,BP.stackObese,BP.stackOverweight)
? BP.newObeseOverweightNormal #? ? CODEA Obese14 Overweight14 Overweight21 Obese21 hibp21? ? ? ? Categ #411? 541? ? ? 0? ? ? ? ? ? 0? ? ? ? ? ? 0? ? ? 0? ? ? 0? ? Normal14 #415? 545? ? ? 0? ? ? ? ? ? 0? ? ? ? ? ? 1? ? ? 1? ? ? 1? ? Normal14 #418? 549? ? ? 0? ? ? ? ? ? 0? ? ? ? ? ? 1? ? ? 0? ? ? 0? ? Normal14 #413? 543? ? ? 1? ? ? ? ? ? 0? ? ? ? ? ? 1? ? ? 1? ? ? 0? ? ? Obese14 #417? 548? ? ? 0? ? ? ? ? ? 1? ? ? ? ? ? 1? ? ? 0? ? ? 0 Overweight14 BP.newObeseOverweightNormal$Categ<- factor(BP.newObeseOverweightNormal$Categ) BP.stack3 <-
reshape(BP.newObeseOverweightNormal,idvar="CODEA",timevar="time",sep="_",varying=list(c("Obese14","Obese21"),c("Overweight14","Overweight21")),v.names=c("Obese","Overweight"),direction="long")
library(car)
BP.stack3$time<-recode(BP.stack3$time,"1=14;2=21")
BP.stack3 #Here Normal14 gets repeated even at time==21.? Given that you
are using the "Categ" and "time" #columns in the analysis, it will give
incorrect results.
#? ? ? CODEA hibp21? ? ? ? Categ time Obese Overweight
#541.1? 541? ? ? 0? ? Normal14? 14? ? 0? ? ? ? ? 0
#545.1? 545? ? ? 1? ? Normal14? 14? ? 0? ? ? ? ? 0
#549.1? 549? ? ? 0? ? Normal14? 14? ? 0? ? ? ? ? 0
#543.1? 543? ? ? 0? ? ? Obese14? 14? ? 1? ? ? ? ? 0
#548.1? 548? ? ? 0 Overweight14? 14? ? 0? ? ? ? ? 1
#541.2? 541? ? ? 0? ? Normal14? 21? ? 0? ? ? ? ? 0
#545.2? 545? ? ? 1? ? Normal14? 21? ? 1? ? ? ? ? 1
#549.2? 549? ? ? 0? ? Normal14? 21? ? 0? ? ? ? ? 1
#543.2? 543? ? ? 0? ? ? Obese14? 21? ? 1? ? ? ? ? 1
#548.2? 548? ? ? 0 Overweight14? 21? ? 0? ? ? ? ? 1
#Even if I correct the above codes, this will give incorrect
results/(error as you shown) because the response variable (hibp21) gets
#repeated when you reshape it from wide to long.
The correct classification might be:
BP_2b<-read.csv("BP_2b.csv",sep="\t")
? BP.sub<-BP_2b[410:418,c(1,8:11,13)]
BP.subnew<-reshape(BP.sub,idvar="CODEA",timevar="time",sep="",varying=list(c("Obese14","Obese21"),c("Overweight14","Overweight21")),v.names=c("Obese","Overweight"),direction="long")
BP.subnew$time<-recode(BP.subnew$time,"1=14;2=21") ? BP.subnew<-na.omit(BP.subnew) BP.subnew$Categ[BP.subnew$Overweight==1 & BP.subnew$time==14 & BP.subnew$Obese==0]<-"Overweight14" BP.subnew$Categ[BP.subnew$Overweight==1 & BP.subnew$time==21 & BP.subnew$Obese==0]<-"Overweight21" ? BP.subnew$Categ[BP.subnew$Obese==1 & BP.subnew$time==14 & BP.subnew$Overweight==0]<-"Obese14" ? BP.subnew$Categ[BP.subnew$Obese==1 & BP.subnew$time==21 & BP.subnew$Overweight==0]<-"Obese21" ? BP.subnew$Categ[BP.subnew$Overweight==1 & BP.subnew$time==21& BP.subnew$Obese==1]<-"ObeseOverweight21" ? BP.subnew$Categ[BP.subnew$Overweight==1 & BP.subnew$time==14& BP.subnew$Obese==1]<-"ObeseOverweight14" BP.subnew$Categ[BP.subnew$Overweight==0 & BP.subnew$Obese==0 &BP.subnew$time==14]<-"Normal14" ? BP.subnew$Categ[BP.subnew$Overweight==0 & BP.subnew$Obese==0 &BP.subnew$time==21]<-"Normal21" BP.subnew$Categ<-factor(BP.subnew$Categ) BP.subnew$time<-factor(BP.subnew$time) BP.subnew #? ? ? CODEA hibp21 time Obese Overweight? ? ? ? ? ? Categ #541.1? 541? ? ? 0? 14? ? 0? ? ? ? ? 0? ? ? ? ? Normal14 #543.1? 543? ? ? 0? 14? ? 1? ? ? ? ? 0? ? ? ? ? Obese14 #545.1? 545? ? ? 1? 14? ? 0? ? ? ? ? 0? ? ? ? ? Normal14 #548.1? 548? ? ? 0? 14? ? 0? ? ? ? ? 1? ? ? Overweight14 #549.1? 549? ? ? 0? 14? ? 0? ? ? ? ? 0? ? ? ? ? Normal14 #541.2? 541? ? ? 0? 21? ? 0? ? ? ? ? 0? ? ? ? ? Normal21 #543.2? 543? ? ? 0? 21? ? 1? ? ? ? ? 1 ObeseOverweight21 #545.2? 545? ? ? 1? 21? ? 1? ? ? ? ? 1 ObeseOverweight21 #548.2? 548? ? ? 0? 21? ? 0? ? ? ? ? 1? ? ? Overweight21 #549.2? 549? ? ? 0? 21? ? 0? ? ? ? ? 1? ? ? Overweight21 #NOw with the whole dataset: BP.sub<-BP_2b[,c(1,8:11,13)] #change here and paste the above lines: ? head(BP.subnew) ? ? # CODEA hibp21 time Obese Overweight? ? Categ #3.1? ? ? 3? ? ? 0? 14? ? 0? ? ? ? ? 0 Normal14 #7.1? ? ? 7? ? ? 0? 14? ? 0? ? ? ? ? 0 Normal14 #8.1? ? ? 8? ? ? 0? 14? ? 0? ? ? ? ? 0 Normal14 #9.1? ? ? 9? ? ? 0? 14? ? 0? ? ? ? ? 0 Normal14 #14.1? ? 14? ? ? 1? 14? ? 0? ? ? ? ? 0 Normal14 #21.1? ? 21? ? ? 0? 14? ? 0? ? ? ? ? 0 Normal14 tail(BP.subnew) ? #? ? CODEA hibp21 time Obese Overweight? ? ? ? ? ? Categ #8485.2? 8485? ? ? 0? 21? ? 1? ? ? ? ? 1 ObeseOverweight21 #8506.2? 8506? ? ? 0? 21? ? 0? ? ? ? ? 1? ? ? Overweight21 #8520.2? 8520? ? ? 0? 21? ? 0? ? ? ? ? 0? ? ? ? ? Normal21 #8529.2? 8529? ? ? 1? 21? ? 1? ? ? ? ? 1 ObeseOverweight21 #8550.2? 8550? ? ? 0? 21? ? 1? ? ? ? ? 1 ObeseOverweight21 #8554.2? 8554? ? ? 0? 21? ? 0? ? ? ? ? 0? ? ? ? ? Normal21 summary(lme.1 <- lme(hibp21~time+Categ+ time*Categ, data=BP.subnew,random=~1|CODEA, na.action=na.omit)) #Error in MEEM(object, conLin, control$niterEM) : ? #Singularity in backsolve at level 0, block 1 #May be because of the reasons I mentioned above. #YOu didn't mention the library(gee) BP.gee8 <- gee(hibp21~time+Categ+time*Categ, data=BP.subnew,id=CODEA,family=binomial, corstr="exchangeable",na.action=na.omit) #Beginning Cgee S-function, @(#) geeformula.q 4.13 98/01/27 #Error in gee(hibp21 ~ time + Categ + time * Categ, data = BP.subnew, id
=
CODEA,? : ? #rank-deficient model matrix With your codes, it might have worked, but the results may be inaccurate # After running your whole codes: ? BP.gee8 <- gee(hibp21~time+Categ+time*Categ, data=BP.stack3,id=CODEA,family=binomial, corstr="exchangeable",na.action=na.omit) #Beginning Cgee S-function, @(#) geeformula.q 4.13 98/01/27 #running glm to get initial regression estimate ? ? #? ? ? ? (Intercept)? ? ? ? ? ? ? ? ? time? ? ? ? ? CategObese14 ? ? ? #? ? -2.456607e+01? ? ? ? ? 9.940875e-15? ? ? ? ? 2.087584e-13 ? ? # CategOverweight14? ? ? time:CategObese14 time:CategOverweight14 ? ? ? #? ? 2.087584e-13? ? ? ? ? -9.940875e-15? ? ? ? ? -9.940875e-15 #Error in gee(hibp21 ~ time + Categ + time * Categ, data = BP.stack3, id
=
CODEA,? : ? # Cgee: error: logistic model for probability has fitted value very
close
to 1. #estimates diverging; iteration terminated. In short, I think it would be better to go with the suggestion in my previous email with adequate changes in "Categ" variable (adding ObeseOverweight14, ObeseOverweight21 etc) as I showed here. A.K. ------------------------------ ? If you reply to this email, your message will be added to the
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