Dear List, We are planning a genotyping study to be analyzed using false discovery rates (FDRs) (See Storey and Tibshirani PNAS 2003; 100:9440-5). I am interested in learning if there is any consensus as to how many features (ie. how many P values) need to be studied before reasonably reliable FDRs can be derived. Does anyone know of a citation where this is discussed? Bill Dupont William D. Dupont phone: 615-343-4100 URL http://biostat.mc.vanderbilt.edu/twiki/bin/view/Main/WilliamDupont
FDR analyses: minimum number of features
3 messages · Dupont, William, Spencer Graves, Kjetil Halvorsen
1 day later
Two thoughts on this: 1. Your FDR (Not Franklin Delano Roosevelt) sounds like another name for Type I error rate. The definition of "reasonably reliable FDRs" would seem to relate to the status of the literature on this issue among researchers in genotyping. As more reports of FRDs in genotyping are published, I would expect that methodology for estimation and the standard for accuracy would similarly evolve. 2. Have you tried the Bioconductor (www.bioconductor.org/) listserve? They might be able to say something more useful than a general list like this. spencer graves
Dupont, William wrote:
Dear List, We are planning a genotyping study to be analyzed using false discovery rates (FDRs) (See Storey and Tibshirani PNAS 2003; 100:9440-5). I am interested in learning if there is any consensus as to how many features (ie. how many P values) need to be studied before reasonably reliable FDRs can be derived. Does anyone know of a citation where this is discussed? Bill Dupont William D. Dupont phone: 615-343-4100 URL http://biostat.mc.vanderbilt.edu/twiki/bin/view/Main/WilliamDupont
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Spencer Graves wrote:
Two thoughts on this: 1. Your FDR (Not Franklin Delano Roosevelt) sounds like another name for Type I error rate.
It is certainly not the same as type I error rate. Type I error rate is the proportion of true nulls which are rejected, while the FDR is the proportion of rejected null hypothesis which really are true nulls! To me FDR seems like a more promising avenue to multiple testing than the old "familywise error rate". Who knows what is a family? Kjetil
The definition of "reasonably reliable FDRs" would seem to relate to the status of the literature on this issue among researchers in genotyping. As more reports of FRDs in genotyping are published, I would expect that methodology for estimation and the standard for accuracy would similarly evolve. 2. Have you tried the Bioconductor (www.bioconductor.org/) listserve? They might be able to say something more useful than a general list like this. spencer graves Dupont, William wrote:
Dear List, We are planning a genotyping study to be analyzed using false discovery rates (FDRs) (See Storey and Tibshirani PNAS 2003; 100:9440-5). I am interested in learning if there is any consensus as to how many features (ie. how many P values) need to be studied before reasonably reliable FDRs can be derived. Does anyone know of a citation where this is discussed? Bill Dupont William D. Dupont phone: 615-343-4100 URL http://biostat.mc.vanderbilt.edu/twiki/bin/view/Main/WilliamDupont
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