Dear all, I have a standard method and two alternatives to perform a test, called method A and method B. I have calculated the sensitivity and specificity for standard method vs. method A and standard method vs. method B. Hence, I have two sensitivity values an two specificity values. To be clear, sensitivity and specificity was calculated from: Disease(A) No Disease(Ac) Total Positive Screen(T) a b a+b Negative Screen(Tc) c d c+d Total a+c b+d a+b+c+d where sensitivity: P(T | A)=a/(a+c) and specificity: P(Tc | Ac)=d/(b+d). My questions: How can I compare this quantities? That is, how method have high sensitivity or specificity? Could I get the empirical distributions for sensitivity and specificity from Bootstrap? If yes, Could I sampling from the set of "all" contingency tables with given marginals, and works only if the marginals are positive? It is the technique used by chisq.test when simulate.p.value is TRUE. Best Regards. LB.
bootstraping sensitivity and specificity
1 message · lamack lamack