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nlme model specification

On Mon, May 26, 2008 at 8:22 AM, Nicholas Lewin-Koh <nikko at hailmail.net> wrote:
I certainly wouldn't want to imply that LRTs are not useful for
mixed-model comparisons, but I think there are some issues that users
should at least be aware of (if lmer has overcome any of these I'd be
interested in hearing about it):

- LRTs aren't valid to compare REML fits with different fixed effects
because REML essentially maximizes A'Y where E[A'Y] = 0, so changing
the fixed effects changes A' which changes the data making the
likelihoods non-comparable.
- Pinheiro and Bates (2000, pg 87-88) recommend LRTs with the standard
X^2 distribution not be used to compare ML fits with different fixed
effects because the tests can be very "anticonservative" --
particularly as the number of parameters being removed becomes large
relative to the number of observations.
- LRTs for differences in the random part of the model when the fixed
effects are the same can be conservative due to the null value of 0
being on the edge of the variance parameter space.
- It seems the issue of counting the number of parameters being
estimated will be an issue when comparing models that differ in their
random effects (i.e. for determining the df of the X^2).

Kingsford Jones