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Best optimizer for large scale problems

On Thu, 06 Jun 2013, Bastian Offermann <bastian2507hk at yahoo.co.uk> writes:
You say you "have tried" these packages, so did you encounter any
specific problems?  If yes, you should post some examples that
demonstrate these problems.

quadprog sounds reasonable, but if your covariance matrix is not
full-rank, quadprog's solve.QP will not work.  (Which is actually more
an empirical than a computational problem.  For example, there might be
no unique solution.)  Other methods, such as Differential Evolution, do
not have such a constraint.

Regards,
        Enrico