simulation of consanguineous unions in human populations with R
Dear list members, I was wondering if anyone had experience simulating non-random mating human populations with R. I want to simulate the evolution of disease susceptibility loci under certain evolutionary scenarios and under specific non-random mating schemes. For example, at each generation, p% of the matings occur between first cousins, offspring from such unions (must) have on average 1/16 of their genome autozygous. I've been exploring simulation softwares for a while , but they offer limited mating schemes, mainly because relationships between individuals can not be extracted. Any ideas or suggestions are welcome ! Thank you .
###################################### Hinda HANED CNRS UMR 5558 - Laboratoire de Biom?trie et Biologie Evolutive Universite Lyon 1 43 bd du 11 novembre 1918 69622 Villeurbanne Cedex T?l. : 04.72.43.27.57 Fax : 04.72.43.13.88 haned at biomserv.univ-lyon1.fr http://lbbe.univ-lyon1.fr/-Haned-Hinda-.html?lang=en