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map algebra with ascii grid

I use Python with Numpy/GDAL python bindings all the time to do  
spatial algebra and manipulate grids. It has all the math functions,  
and in the case of categorical data you can reassign values. Then I  
use rpy to do any statistical analyses in R. You could also do your  
manipulation in Python, then save the grid in an appropriate format  
for import into R to do the statistical analyses.

Philip