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Cannot cahnge working directory

In 2.7.0 I am getting an error with setwd not encountered in 2.6.2


setwd("/Users/markgrant/Documents/_projects/genetic/r")

gives

Error in setwd("/Users/markgrant/Documents/_projects/genetic/r") :
   cannot change working directory

However, I can change the working directory from the GUI

Any ideas?

Mark Grant