[R-meta] Correction for sample overlap in a meta-analysis of prevalence
Dear all, I want to conduct a meta-analysis of around 30 studies (from a systematic review). Some background of the studies: The quantity of interest is the prevalence of RSV infection. Different studies reported RSV prevalence for different risk groups. Since, it is quite often that some people might suffer from multiple comorbidities (for example, an individual might have both cardiac disease and lung disease), and it was not stated clearly in the reported data if these two sub-populations (cardia disease patients, and lung disease patients) are mutually exclusive. In the end, I want to have an overall estimate across all risk groups. Given the fact stated above, it is likely that some of the data (from two or more risk groups) might share a proportion of the population. For example, John's study reported data on cardiac disease as well as lung disease. These two risk groups were included in the meta-analysis. However, we need to take into account the fact that, the two sub-populations might share some proportions of participants. I was searching on the internet methods to account for the overlap samples while conducting meta-analysis. There are two papers that address this problem: 1. https://academic.oup.com/bioinformatics/article/33/24/3947/3980249 The authors proposed FOLD, a method to optimize power in a meta-analysis of genetic associations studies with overlapping subjects. 2. http://www.stiftung.at/wp-content/uploads/2015/04/BomPaper_Oct_2014.pdf In this paper, the author compared generalized weights and inverse-variance weights meta-estimates to account for overlap sample. My question is: Are these approaches incorporated into the *metafor* package? Thanks for your input. Best, Thao
*Tr?n Mai Ph??ng Th?o* Master Student - Master of Statistics Hasselt University - Belgium. Email: Thaobrawn at gmail.com / maiphuongthao.tran at student.uhasselt.be Phone number: + 84 979 397 410+ 84 979 397 410 / 0032 488 0358430032 488 035843 [[alternative HTML version deleted]]