[R-meta] Meta-Analisys whit events numbers, RR, OR and HR. It's possibe?
Dear Martin, To add to Guido's answer, it seems that there is something wrong with your odds ratios. You see this when you use Guido's code: For the last two studies, the confidence intervals differ markedly from the entered values: Entered:
OR (0,47 , 0.77, 072) IC95% L (0.24, 0.52, 0.55) IC95% U (0.91, 0.81, 0.89)
Result: [...] study 5?? 0.47 [0.24; 0.92]?? OR study 6?? 0.77 [0.62; 0.96] ? OR study 7?? 0.72 [0.57; 0.92] ? OR You also see this when looking whether the point estimate is the geometric mean (square root of the product) of upper and lower limit of the 95% CI - this is not the case for these studies. Please check. Moreover, as I wrote before, the main problem is not a technical one (how to use R to mix these data), but a methodological issue. HR and OR don't describe the same thing. The heading is "Hazard ratio", because this is what you have written. Nevertheless, the odds ratios remain odds ratios and have a different interpretation. I don't know how to interpret the final result. Both Guido and I recommended the Tierney paper to you, so please have a look into it. Best, Gerta
Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials. 2007;8:16.