[R-meta] I have any problems with meta-analysis of proportions
Comments in-line
On 05/04/2021 17:32, Martin Lobo wrote:
Hi everyone, I performed a systematic review on the persistence of some drugs. I found 30 randomized clinical trials and 10 observational studies. Although I understand that they should not be meta analyzed together (I should stratify them or analyze them separately), Actually, of the RCTs, I only use the active drug arm, so I think that by breaking the branching, maybe I could take all the data as observational.
Yes, you now have a set of observational studies if you only take one arm from the trials.
Is this correct ? If so, how do I describe the methodological part, what guidelines and quality scales should I use (PRISMA, STROBE, COCHRANE, NOS, JADAD?).
It is still a meta-analysis so use PRISMA
On the other hand, I have never performed meta-analysis of proportions, and I am having too much heterogeneity I2 97%. How could I control this? The studies are of good quality. I use the metaprop function.
In a meta-analysis of observational studies high heterogeneity is almost ineitable.
Than's Lorenzo Mart?n Lobo MTSAC, FACC, FESC Especialista Jerarquizado en Cardiolog?a Jefe de Dpto Enf. Cardiovasculares y Cardiometabolismo Hospital Militar Campo de Mayo. Jefe de Cardiolog?a Hospital Militar Campo de Mayo Ex Jefe de Unidad Coronaria Hospital Militar Campo de Mayo Miembro Titular de la Sociedad Argentina de Cardiolog?a Fellow American College of Cardiology Fellow European Society of Cardiology Ex Miembro del Area de Investigaci?n de la SAC Ex Director del Consejo de Aterosclerosis y Trombosis de la SAC Miembro Asesor del Consejo de Aterosclerosis y Trombosis de la SAC Ex Director del Consejo de Epidemiolog?a y Prevenci?n Cardiovascular de la SAC Miembro Asesor del Consejo de Epidemiolog?a y Prevenci?n Cardiovascular de la SAC Experto en Lipidos de la Sociedad Argentina de Lipidos. Miembro de la Sociedad Argentina de Lipidos. Instructor de ACLS de la American Heart Association
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De: R-sig-meta-analysis <r-sig-meta-analysis-bounces at r-project.org> en nombre de r-sig-meta-analysis-request at r-project.org <r-sig-meta-analysis-request at r-project.org>
Enviado: s?bado, 31 de octubre de 2020 08:05
Para: r-sig-meta-analysis at r-project.org <r-sig-meta-analysis at r-project.org>
Asunto: R-sig-meta-analysis Digest, Vol 41, Issue 19
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Today's Topics:
1. Re: GOSH plots for multi-level meta (rma.mv) (Hellen Mirr)
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Message: 1
Date: Fri, 30 Oct 2020 13:03:34 +0000
From: Hellen Mirr <hellenmir554 at gmail.com>
To: "Viechtbauer, Wolfgang (SP)"
<wolfgang.viechtbauer at maastrichtuniversity.nl>
Cc: "r-sig-meta-analysis at r-project.org"
<r-sig-meta-analysis at r-project.org>
Subject: Re: [R-meta] GOSH plots for multi-level meta (rma.mv)
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Dear Wolfgang,
Thank you very much for your clear explanation.
Best,
Hellen
On Fri, Oct 30, 2020 at 11:48 AM Viechtbauer, Wolfgang (SP) <
wolfgang.viechtbauer at maastrichtuniversity.nl> wrote:
Dear Hellen,
This is currently not implemented in metafor. In principle, the idea of a
GOSH plot does generalize to more complex models although one needs to
think about whether one would want to create subsets based on the indiviual
estimates or based on some higher-level grouping variable. For example,
suppose we have a multilevel structure such as:
study esid yi vi
------------------
1 1 . .
1 2 . .
2 1 . .
3 1 . .
3 2 . .
3 3 . .
4 1 . .
So, what are, for example, then the subsets of size 2? Are they based just
on the rows? Then the estimates in row 1 and 2 would be one such subset. Or
does one base the subsets on the studies? Then rows 1, 2, 3 (i.e., studies
1 and 2) would be such a subset.
This could all be implemented (just like cooks.distance() and rstudent()
allow for the optional specification of a clustering variable), but I
haven't done this.
Aside from that: Fitting rma.mv models can take a bit of time. Doing this
1000's of times (based on all possible subsets) could take a LONG time.
Best,
Wolfgang
-----Original Message-----
From: R-sig-meta-analysis [mailto:
r-sig-meta-analysis-bounces at r-project.org]
On Behalf Of Hellen Mirr
Sent: Friday, 30 October, 2020 12:12
To: r-sig-meta-analysis at r-project.org
Subject: [R-meta] GOSH plots for multi-level meta (rma.mv)
Hello,
Apologies if this has already been answered, as I could not find any
threads on it.
I was wondering whether it is possible to create a GOSH plot for a
multi-level meta analysis that is an rma.mv object, and how I would go
about that.
[[elided Hotmail spam]]
Best wishes
Hellen
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