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[R-meta] Additional Info: Pairwise moderator testing in multilevel meta-analysis with CRVE / CIs

Hi James,

thank you very much! This helps me a lot!

Best regards,
Sebastian

-----Urspr?ngliche Nachricht-----
Von: R-sig-meta-analysis <r-sig-meta-analysis-bounces at r-project.org> Im Auftrag von James Pustejovsky via R-sig-meta-analysis
Gesendet: Freitag, 10. Februar 2023 15:12
An: R Special Interest Group for Meta-Analysis <r-sig-meta-analysis at r-project.org>
Cc: James Pustejovsky <jepusto at gmail.com>
Betreff: Re: [R-meta] Additional Info: Pairwise moderator testing in multilevel meta-analysis with CRVE / CIs

Hi Sebastian,

Pairwise tests are definitely possible when using CRVE. The issue is that overlap of confidence intervals is not generally a valid method for gauging statistical significance of differences.

When comparing the means of *independent* samples, confidence interval overlap is conservative, so overlap does not imply statistical non-significance of differences in means. See Schenker & Gentleman (2001; https://doi.org/10.1198/000313001317097960), Austin & Hux (2002;
https://doi.org/10.1067/mva.2002.125015) or many others.

If the means are from *dependent* samples (as could be the case for your meta-regression results), there is no direct correspondence between CI overlap and statistical significance. This is because the SE for the difference in means depends not just on the SEs for the means but also on the sampling covariance between them. As a simple example, consider the confidence intervals for the means of A and B, based on a sample of N = 100 from a bivariate normal distribution where meanB = meanA + 0.1, sdA = sdB = 1, and cor(A,B) = 0.9. The confidence intervals will have a probability of overlapping but the difference in means will be fairly precisely estimated because the correlation is so high.

James
On Fri, Feb 10, 2023 at 2:50 AM R?hl, Sebastian via R-sig-meta-analysis < r-sig-meta-analysis at r-project.org> wrote:

            
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