[R-meta] Fwd: meta analysis package "metafor" --- one group survival outcome?
Dear Hong Comment in-line
On 28/06/2017 03:25, Hong Zhao wrote:
Dear all, I have a question for R package "metafor". On page 35 of the package file, I saw the meta-analysis for a two sample survival analysis, does anyone know whether I can use this package to do one-sample survival analysis? Here is what I have: three 3 studies with all the survival information (time to event and censor information). I want to combine the survival rates (KM estimates) at 6 months for these 3 studies using meta-analysis. Since the survival rates are not normally distributed and I cannot just simply treat them as proportions to use meta-analysis method for normal data or proportion data, I am not sure whether I can just transform them using log(survival rate) (and get their variance accordingly) and use meta-analysis for normal data. Does anyone know a better way to do it? Or can the package perform the meta-analysis for a single group survival outcome?
I think you are looking for incidence rates here. There are some options outlined in the documentation for escalc under the heading methods for event counts.
BTW, does anyone know any method for sample size calculation for meta-analysis (outcome is one-sample binomial or survival outcome as I mentioned above)? I want to perform non-inferiority test, but did not find anything available from online for meta-analysis sample size calculation for either binomial or survival outcome. I guess I may need to just do simulation if there is no available sources.
Why not just do your analysis and report confidence intervals? It is not like a trial where you can always recruit a few more cases so knowing you need 100 primary studies is hardly going to help if only seven exist.
Thanks so much for your kind help! Best! [[alternative HTML version deleted]]
In this case it did not matter but this is a plain text list and sending HTML mangles your message.
_______________________________________________ R-sig-meta-analysis mailing list R-sig-meta-analysis at r-project.org https://stat.ethz.ch/mailman/listinfo/r-sig-meta-analysis --- This email has been checked for viruses by AVG. http://www.avg.com