[R-meta] I have any problems with meta-analysis of proportions

Fri, Apr 9, 2021 6:07 AM

Dear Martin

On 08/04/2021 17:15, Martin Lobo wrote:

That seems to me wrong. It is a meta-analysis so it needs to be reported 
and assessed as a meta-analysis. What you would use for the primary 
studies is irrelevant. After all for a meta-analysis of randomised 
trials you would use PRISMA and CONSORT.

As far as heterogeneity is concerned I would not be bothered about it. 
In a m-a of observational studies it is to be expected. After all, 
suppose you did a study on a condition with a global impact. Would you 
expect to see the same results in Algeria, Angola, Argentina, Australia, 
Austria, ...? One thing I would suggest, following on from an insightful 
comment by Nicky in an earlier part of the thread is that you include a 
moderator with two levels: study was a trial, study was a cohort. This 
would help to account for the probably differences in case-mix between 
the two sorts of study. I would also suggest that you incorporate 
prediction intervals as these may be more be beneficial in generalising 
your results.

For some helpful comments about heterogeneity see

@article{rucker08b,
    author = {R\"ucker, G and Schwarzer, G and Carpenter, J R and
       Schumacher, M},
    title = {Undue reliance on {$I^2$} in assessing heterogeneity
       may mislead},
    journal = {BMC Medical Research Methodology},
    year = {2008},
    volume = {8},
    number = {79},
    keywords = {meta-analysis, heterogeneity}
}


For prediction intervals see

@article{riley11,
    author = {Riley, R D and Higgins, J P T and Deeks, J J},
    title = {Interpretation of random effects meta--analyses},
    journal = {British Medical Journal},
    year = {2011},
    volume = {342},
    pages = {964--967},
    keywords = {meta-analysis, random effects}
}

*Lukasz,*
*
*
In some of my examples the I2 is 97%, T2 (square tau)0.06 (0 <0.01), in 
this case how would you consider heterogenicity?
the proportion estimates vary from 0.28 to 0.59.

Thank's for your help

Regards



*/
/*
*/Lorenzo Mart?n Lobo /**/^MTSAC, FACC, FESC /*
/*Especialista Jerarquizado?en Cardiolog?a*/
/*/*Jefe de Dpto Enf. Cardiovasculares y Cardiometabolismo Hospital 
Militar Campo de Mayo.*/
*/
/*/*Jefe de Cardiolog?a *//*Hospital Militar Campo de Mayo*/
*/
/*Ex?Jefe de Unidad Coronaria *//*Hospital Militar Campo de Mayo*/
/
/*Miembro Titular de la Sociedad Argentina de Cardiolog?a*/
/
/
/*Fellow American College of Cardiology*/
/
/
/*Fellow European Society of Cardiology*/
/
/
/*/*Ex Miembro del Area de Investigaci?n de la SAC*/*/
/
/*Ex Director del Consejo de Aterosclerosis y Trombosis de la SAC*/
/*Miembro Asesor /*del Consejo de Aterosclerosis y Trombosis de la SAC*/*/
/*/
/*/
/*Ex Director del Consejo de Epidemiolog?a y Prevenci?n Cardiovascular 
de la SAC*/
/*/
/*/
/*/
/*//*/
/*/
/*Miembro Asesor?del Consejo de Epidemiolog?a y Prevenci?n 
Cardiovascular de la SAC*/
/*/
/*/
/*/
/*/
/*Experto en Lipidos de la Sociedad Argentina de Lipidos.*/
/*Miembro de la Sociedad Argentina de Lipidos.*/
/
/*Instructor de ACLS de la American Heart Association*/
/


------------------------------------------------------------------------
*De:* Michael Dewey <lists at dewey.myzen.co.uk>
*Enviado:* martes, 6 de abril de 2021 05:48
*Para:* Martin Lobo <mlobo4370 at hotmail.com>; 
r-sig-meta-analysis at r-project.org <r-sig-meta-analysis at r-project.org>
*Asunto:* Re: [R-meta] I have any problems with meta-analysis of 
proportions
Comments in-line

On 05/04/2021 17:32, Martin Lobo wrote:

Hi everyone,

I performed? a systematic review on the persistence of some drugs.
I found 30 randomized clinical trials and 10 observational studies.
Although I understand that they should not be meta analyzed together (I should stratify them or analyze them separately), Actually, of the RCTs, I only use the active drug arm, so I think that by breaking the branching, maybe I could take all the data as  observational.

Yes, you now have a set of observational studies if you only take one
arm from the trials.

Is this correct ?
If so, how do I describe the methodological part, what guidelines and quality scales should I use (PRISMA, STROBE, COCHRANE, NOS, JADAD?).

It is still a meta-analysis so use PRISMA

On the other hand, I have never performed meta-analysis of proportions, and I am having too much heterogeneity I2 97%. How could I control this? The studies are of good quality. I use the metaprop function.

In a meta-analysis of observational studies high heterogeneity is almost
ineitable.

Than's




Lorenzo Mart?n Lobo MTSAC, FACC, FESC
Especialista Jerarquizado en Cardiolog?a
Jefe de Dpto Enf. Cardiovasculares y Cardiometabolismo Hospital Militar Campo de Mayo.
Jefe de Cardiolog?a Hospital Militar Campo de Mayo
Ex Jefe de Unidad Coronaria Hospital Militar Campo de Mayo
Miembro Titular de la Sociedad Argentina de Cardiolog?a
Fellow American College of Cardiology
Fellow European Society of Cardiology
Ex Miembro del Area de Investigaci?n de la SAC
Ex Director del Consejo de Aterosclerosis y Trombosis de la SAC
Miembro Asesor del Consejo de Aterosclerosis y Trombosis de la SAC
Ex Director del Consejo de Epidemiolog?a y Prevenci?n Cardiovascular de la SAC

Miembro Asesor del Consejo de Epidemiolog?a y Prevenci?n Cardiovascular de la SAC


Experto en Lipidos de la Sociedad Argentina de Lipidos.
Miembro de la Sociedad Argentina de Lipidos.
Instructor de ACLS de la American Heart Association

________________________________
De: R-sig-meta-analysis <r-sig-meta-analysis-bounces at r-project.org> en nombre de r-sig-meta-analysis-request at r-project.org <r-sig-meta-analysis-request at r-project.org>
Enviado: s?bado, 31 de octubre de 2020 08:05
Para: r-sig-meta-analysis at r-project.org <r-sig-meta-analysis at r-project.org>
Asunto: R-sig-meta-analysis Digest, Vol 41, Issue 19

Send R-sig-meta-analysis mailing list submissions to
????????? r-sig-meta-analysis at r-project.org

To subscribe or unsubscribe via the World Wide Web, visit
         https://na01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fstat.ethz.ch%2Fmailman%2Flistinfo%2Fr-sig-meta-analysis&amp;data=04%7C01%7C%7C07641839b35b4b7e880508d8f8d8c01c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637532957104482831%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&amp;sdata=sGfmNpcjiD9QdRCYuQfBYDE%2B92sbWCbnapD4QgP0D5c%3D&amp;reserved=0

<https://na01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fstat.ethz.ch%2Fmailman%2Flistinfo%2Fr-sig-meta-analysis&amp;data=04%7C01%7C%7C07641839b35b4b7e880508d8f8d8c01c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637532957104482831%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&amp;sdata=sGfmNpcjiD9QdRCYuQfBYDE%2B92sbWCbnapD4QgP0D5c%3D&amp;reserved=0>

or, via email, send a message with subject or body 'help' to
????????? r-sig-meta-analysis-request at r-project.org

You can reach the person managing the list at
????????? r-sig-meta-analysis-owner at r-project.org

When replying, please edit your Subject line so it is more specific
than "Re: Contents of R-sig-meta-analysis digest..."


Today's Topics:

???? 1. Re: GOSH plots for multi-level meta (rma.mv) (Hellen Mirr)

----------------------------------------------------------------------

Message: 1
Date: Fri, 30 Oct 2020 13:03:34 +0000
From: Hellen Mirr <hellenmir554 at gmail.com>
To: "Viechtbauer, Wolfgang (SP)"
????????? <wolfgang.viechtbauer at maastrichtuniversity.nl>
Cc: "r-sig-meta-analysis at r-project.org"
????????? <r-sig-meta-analysis at r-project.org>
Subject: Re: [R-meta] GOSH plots for multi-level meta (rma.mv)
Message-ID:
????????? <CAF6nRJqkgQ4_vkF0sdf=_anW2Etp2snB14F-v0ot8rZ9JFaXGQ at mail.gmail.com>
Content-Type: text/plain; charset="utf-8"

Dear Wolfgang,

Thank you very much for your clear explanation.

Best,
Hellen

On Fri, Oct 30, 2020 at 11:48 AM Viechtbauer, Wolfgang (SP) <
wolfgang.viechtbauer at maastrichtuniversity.nl> wrote:

Dear Hellen,

This is currently not implemented in metafor. In principle, the idea of a
GOSH plot does generalize to more complex models although one needs to
think about whether one would want to create subsets based on the indiviual
estimates or based on some higher-level grouping variable. For example,
suppose we have a multilevel structure such as:

study? esid? yi vi
------------------
1????? 1???? .? .
1????? 2???? .? .
2????? 1???? .? .
3????? 1???? .? .
3????? 2???? .? .
3????? 3???? .? .
4????? 1???? .? .

So, what are, for example, then the subsets of size 2? Are they based just
on the rows? Then the estimates in row 1 and 2 would be one such subset. Or
does one base the subsets on the studies? Then rows 1, 2, 3 (i.e., studies
1 and 2) would be such a subset.

This could all be implemented (just like cooks.distance() and rstudent()
allow for the optional specification of a clustering variable), but I
haven't done this.

Aside from that: Fitting rma.mv models can take a bit of time. Doing this
1000's of times (based on all possible subsets) could take a LONG time.

Best,
Wolfgang

-----Original Message-----
From: R-sig-meta-analysis [mailto:

r-sig-meta-analysis-bounces at r-project.org]

On Behalf Of Hellen Mirr
Sent: Friday, 30 October, 2020 12:12
To: r-sig-meta-analysis at r-project.org
Subject: [R-meta] GOSH plots for multi-level meta (rma.mv)

Hello,

Apologies if this has already been answered, as I could not find any
threads on it.
I was wondering whether it is possible to create a GOSH plot for a
multi-level meta analysis that is an rma.mv object, and how I would go
about that.

[[elided Hotmail spam]]

Best wishes
Hellen

????????? [[alternative HTML version deleted]]




------------------------------

Subject: Digest Footer

_______________________________________________
R-sig-meta-analysis mailing list
R-sig-meta-analysis at r-project.org
https://na01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fstat.ethz.ch%2Fmailman%2Flistinfo%2Fr-sig-meta-analysis&amp;data=04%7C01%7C%7C07641839b35b4b7e880508d8f8d8c01c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637532957104482831%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&amp;sdata=sGfmNpcjiD9QdRCYuQfBYDE%2B92sbWCbnapD4QgP0D5c%3D&amp;reserved=0

_______________________________________________
R-sig-meta-analysis mailing list
R-sig-meta-analysis at r-project.org
https://na01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fstat.ethz.ch%2Fmailman%2Flistinfo%2Fr-sig-meta-analysis&amp;data=04%7C01%7C%7C07641839b35b4b7e880508d8f8d8c01c%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637532957104482831%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&amp;sdata=sGfmNpcjiD9QdRCYuQfBYDE%2B92sbWCbnapD4QgP0D5c%3D&amp;reserved=0

Michael
http://www.dewey.myzen.co.uk/home.html

[R-meta] I have any problems with meta-analysis of proportions

Thread (7 messages)