Dear Giorgio This may be related to a long discussion on this list recently. You can see the original post https://stat.ethz.ch/pipermail/r-sig-meta-analysis/2020-May/002082.html and then follow the rest of a quite extensive thread. I am not sufficiently expert in time-to-event studies to say whether it does answer your question but it might be informative. Michael
On 31/05/2020 19:27, Giorgio Maria Agazzi wrote:
Dear all, I am planning to do a meta-regression with the intent to compare trial patient characteristics to the incidence of an outcome in the time period between t=0 and t=2 years. Every study reports the number at risk at t=0 and t=2 years and the kaplan-meier curve, so I'm able to digitize the curve and extract the percentages of events. I was thinking of doing a meta-regression and using as effect size the freeman-tukey transformed incidence rate. I'm not sure this is the best way and I have also another question, how can I calculate the total number at risk as requested by metafor? for the number of events I can calculate it by digitizing the plot and calculating the percentage of people that had the outcome. Thank you very much! gma [[alternative HTML version deleted]]
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