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estimating variance components for arbitrarily defined var/covar matrices

Hi all,

This has been wonderful to follow, thank you very much to all who have
contributed!!

Quick clarification:
Z*Z' is fixed/known. VG is unknown and would be estimated from the data.

Another issue:
The number of individuals fit in these models is often very large (e.g.,
10K - 100K) because the variance of the off-diagonals of Z*Z' is tiny. Of
the above approaches suggested, are any able to work with datasets of this
size in a 'reasonable' amount of time? E.g., < 1 day?

Best,

Matt

On Thu, Feb 26, 2015 at 2:47 PM, Rolf Turner <r.turner at auckland.ac.nz>
wrote: