Questions about design and convergence warnings

Dear Umber,

Can you clarify what a tissue is? Distinct parts of an organ (tissue 1
for organ 1 refers to the same part as tissue 1 for organ 2)? Or
merely different samples for the same organ (no link between tissue 1
between organs). Tissue as random effect is only relevant in the first
case. In the latter case is depends on the number of replicates per
tissue:organ. In case of one replication go for (1|Organ), in case of
multiple replications go for (1|Organ/Tissue).

It looks like you have very strong species effects. That is an
indication for quasi-complete separation, which can trigger
convergence warnings.

Best regards,

ir. Thierry Onkelinx
Statisticus/ Statistician

Vlaamse Overheid / Government of Flanders
INSTITUUT VOOR NATUUR- EN BOSONDERZOEK / RESEARCH INSTITUTE FOR NATURE
AND FOREST
Team Biometrie & Kwaliteitszorg / Team Biometrics & Quality Assurance
thierry.onkelinx at inbo.be
Kliniekstraat 25, B-1070 Brussel
www.inbo.be

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more than asking him to perform a post-mortem examination: he may be
able to say what the experiment died of. ~ Sir Ronald Aylmer Fisher
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not ensure that a reasonable answer can be extracted from a given body
of data. ~ John Tukey
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2017-09-28 16:58 GMT+02:00 Dube, Umber <udube at wustl.edu>:

Questions about design and convergence warnings

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