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dropping interaction terms

Dear all,

I have a simple design with two factors (each with two levels) and their
interaction term. I am analyzing it with mixed models.

The interaction term is not significant. Do I need to fit another model
without the interaction term before performing post-hoc tests, or is it
more appropriate to perform post-hoc tests on the full model with the
non-significant interaction term?

Thanks for your help

Best
Cristiano