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glmmADMB fails to fit poisson data

With count data where the mean is large, there?s a strong case to
be made for finding a suitable power transform of (count+1) and
using a normal theory model.  If differences in residual variance
are evident, these can be accommodated by assigning weights.
Functions for getting diagnostics are better developed for the
normal theory models, and easier to interpret.

For the analysis of RNA-Seq data, there is a paper that compares
the two styles of model:

Law, CW, Chen, Y, Shi, W, Smyth, GK (2014). Voom: precision weights unlock linear model analysis tools for RNA-seq read counts. Genome Biology 15, R29.http://genomebiology.com/2014/15/2/R29

NB also the recent paper:

Schurch NJ, Schofield P, Gierli?ski M, Cole C, Sherstnev A, Singh V, Wrobel N, Gharbi K, Simpson GG, Owen-Hughes T, Blaxter M, Barton GJ (2016). How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use? RNA http://www.rnajournal.org/cgi/doi/10.1261/rna.053959.115

The log(count+1) approach is the best, or close to the best, in the field.

John Maindonald             email: john.maindonald at anu.edu.au