R2 measure in mixed models?
Hi David, How would you go about summarizing the how much variation a SNP (fixed effect) explains (in the mixed model setting)/ or the "strength" of the SNP. Thanks, Juliet
On Mon, Mar 1, 2010 at 6:39 PM, David Duffy <David.Duffy at qimr.edu.au> wrote:
On Mon, 1 Mar 2010, Juliet Hannah wrote:
How does one try and summarize the "strength" of a fixed effect in the mixed model setting? It is this question that had led me to try and understand the various pseudo R-squares. I'm curious how others do this (for any definition of strength). On Fri, Feb 26, 2010 at 10:27 AM, Nick Isaac <njbisaac at googlemail.com> wrote:
Thanks for these pertinent comments. I can't comment on the motivation for the original post. I have always felt that a single dimensionless Rsq was fairly meaningless in the context of mixed models. Gelman & Pardoe's formula summarizes the fit at each level in the model separately. This has more intuitive appeal, especially since I tend to fit models containing fixed effects at the group level.
In other words, what's the purpose? ?What aspect of the R^2 for a linear model are you trying to generalize? I'm sorry if I sound argumentative but discussions like this sometimes frustrate me. ?A linear mixed model does not behave exactly like a linear model without random effects so a measure that may be appropriate for the linear model does not necessarily generalize. In a linear model the R^2 statistic is a dimensionless comparison of the quality of the current model fit, as measured by the residual sum
I have been following this discussion with great interest, and don't pretend to have any answers. ?But, isn't all this only a problem for a MIXED model? That is, if you made all your variables random effects, then proportion of variation due to X (in the given population at the given time, yada yada) again becomes meaningful? In the genetics context, where we are usually interested in the random effects, the "R2" for a given random effect often does strange things depending on which fixed effects one conditions on. Another 2c. ?David Duffy -- | David Duffy (MBBS PhD) ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ,-_|\ | email: davidD at qimr.edu.au ?ph: INT+61+7+3362-0217 fax: -0101 ?/ ? ? * | Epidemiology Unit, Queensland Institute of Medical Research ? \_,-._/ | 300 Herston Rd, Brisbane, Queensland 4029, Australia ?GPG 4D0B994A v
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