On Wed, 17 Jun 2009, Douglas Bates wrote:
On Tue, Jun 2, 2009 at 10:05 PM, David Duffy<David.Duffy at qimr.edu.au> wrote:
On Tue, 2 Jun 2009, Ben Bolker wrote:
?Request for comment: would it be reasonable to have the
"coef" method for "summary.mer" objects return the table
of parameter values, standard errors etc.?
Yes please, oh and a profile likelihood based confint.lmer() too,
thanks ;).
I have been thinking about this recently and I have a way of
constructing a profile likelihood for the variance component
parameters. ?Are those the parameters that are of interest or are you
more interested in the fixed-effects parameters?
Yes, the variance components are of direct interest.
Yet somehow the variability in estimates of variance components in
much more complicated models can be expressed by quoting a standard
error.
Yes, we usually try and produce appropriate confidence intervals and/or
interpretable likelihood based test statistics. ?The latter, of course,
are tricky mixtures for multivariate hypotheses -- a typical one for us is
a variance components linkage analysis test that the common component due
a particular genome region is zero for three measures (repeated at 3
occasions, but with differing contributions by occasion). ?People still
want a P-value, so they can carry out adjustment for genome-wide testing
(linkage is supposed to be roughly equivalent to 50-60 tests for a human
length genome, but the genome-wide corrected 5% P-value is usually quoted
as 2e-5).
Cheers, David Duffy.
?Fixed effect profiles are interesting too (to me) ... I have written
some of my own code to do this (happy to make it available), but it's
not very general/robust at the moment.